Animal Models for Studying Phosphorylation Events

Animal Models for Studying Phosphorylation Events

INQUIRY

Creative BioMart has a wealth of experience and expertise to provide our customers with the ideal custom animal models used to study phosphorylation events to drive their entire project process. Our scientific team and project managers will work closely with our customers to develop and optimize the work plan tailored to their projects.

Background

Kinase-mediated phosphorylation is one of the most common post-translational modifications and can be reversed by phosphatases. Phosphorylation events can act as a molecular switch to regulate protein function in response to extracellular stimuli, mediate protein-protein interactions, or direct proteins to different parts of the cell. Phosphorylation is one of the initial steps in coordinating physiological functions such as cell proliferation, apoptosis, metabolism, and intracellular trafficking. Dysregulation of phosphorylation has been identified as the molecular basis of several important diseases, such as Alzheimer's disease (AD), cancer, and rheumatoid arthritis.

Animal models have been used as important research tools in life sciences and biomedicine to address a variety of scientific questions ranging from basic science to obtaining key information about the prevention, diagnosis, and treatment of diseases. In kinase/phosphatase biology, animal models provide the opportunity to address the role of kinases and phosphatases in vivo and provide in vivo evidence for the regulatory role of phosphorylation. Carefully designed and well-characterized animal models are also essential for drug development to bridge the gap between basic sciences and clinical research. 

Species Options

Creative BioMart provides a wide range of species and flexible options for custom animal model generation. If you can’t find your species of interest, please fill out the online inquiry form and let us know how we can help.

• Mice

  • APOE mice
  • BALB/c mice
  • C57bl/6 mice
  • KM mice
  • Nude mice
  • SCID mice

• Rats

  • BDIX rats
  • Copenhagen rats
  • FHH rats
  • Nude Rats
  • Sprague-Dawley rats
  • Wistar rats

• Rabbits

  • Japanese white rabbits
  • New Zealand white rabbits
  • FHH rats
  • Nude Rats
  • Sprague-Dawley rats

• Guinea Pigs

  • Dunkin-Hartley guinea pigs

• Hamsters

  • Syrian golden hamsters

• Gerbils

  • Mongolian Gerbil

• Drosophila

• C. elegans

• Zebrafish

Technique Options

Creative BioMart offers a range of techniques for different research purposes. Our technology platform is also constantly being expanded and updated.

CRISPR-Mediated Genome Editing	RNAi-Mediated Gene Silencing
Used to generate animal models at various developmental stages in a variety of species. Generate knockin, knockout or knockdown animal models.	Inducible and reversible RNA interference to salience gene of interest. Generate knockdown or knockout animal models.
ESC-Based Gene Targeting	Transposon-Mediated Genome Manipulation
ESC clones containing engineered gene targeting structures are injected into blastocysts to obtain germline transmission. Generate knockin or knockout animal models.	Sleeping Beauty (SB), PiggyBac (PB), and Tol2 Transposon can be used as natural DNA transfer vehicles for efficient genomic insertion. Modeling Insertional mutagenesis.

Service Options

Creative BioMart is committed to providing high-quality custom animal models to researchers worldwide. Our experienced scientific team with extensive knowledge in kinase/phosphatase biology offers an integrated solution for the generation and maintenance of your ideal animal models.

Transgenic Animal Models

We provide multiple types of transgenic animal models including but not limited to constitutive knockout, conditional knockout, functional knockout, constitutive knockin, point mutation knockin models. We can customize animal models for targeted research of kinases, phosphatases, and phosphoproteins.

Animal Disease Models

Since phosphorylation is closely associated with many diseases, we have established a service platform to provide animal disease models according to customer needs to facilitate their elucidation of the crosstalk between phosphorylation and diseases for drug discovery.

Animal Models for Imaging

Animal models are important tools for in vivo studies. We provide bioluminescent animal models for in vivo imaging of phosphorylation events to help customers obtain better visualization results.

Service Workflow

Why Choose Us

Creative BioMart is an advanced biotechnology company providing comprehensive services and products to customers engaged in kinase/phosphatase biology research and drug discovery. Our scientific team will work closely with our customers to ensure that the animal models we provide will actually meet their expectations. If you require further information about any of our services or products, please feel free to contact us at any time. We will get in touch with you as soon as possible.

References

• Briner A, et al. Fyn kinase controls tau aggregation in vivo. Cell Reports, 2020, 32(7): 108045.
• Götz J, et al. Animal models reveal role for tau phosphorylation in human disease. Biochimica et Biophysica Acta (BBA)-Molecular Basis of Disease, 2010, 1802(10): 860-871.