Antibody Analysis for Phosphorylation Research
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INQUIRYCreative BioMart provides a full suite of antibody analysis services to support kinase/phosphatase biology research and pharmaceutical development projects. As a leading biotechnology company with extensive experience in antibody development, we offer our customers with tailor-made services and are confident to complete challenging projects in a short amount of time.
Introduction to Antibody Analysis
Antibodies, also known as immunoglobulins, are protective proteins produced by the body's immune system. The specific interaction between antibodies and antigens has made them a versatile tool in both basic and clinical research, providing scientists with significant data to support their studies. Antibody products, especially monoclonal antibodies, also play an important role in the global biological drugs market. In the field of kinase/phosphatase biology, antibodies have always been an indispensable research tool. Kinases and phosphatases are also excellent examples of druggable molecular targets for therapeutic antibodies available for further development.
The complexity of antibody products makes their development and manufacture present some unique challenges. A “good” antibody should be able to detect the targets in a given assay with assured reproducibility and batch-to-batch consistency. In the development and production of antibody as research tools and therapeutics, the detection, characterization and quantification of important parameters such as impurities, structure, affinity, and immunogenicity are essential to monitor the quality of the final products, which emphasizes the importance of efficient and comprehensive antibody analysis.
Figure 1. Specificity and sensitivity of polyclonal anti-ERK8 antibody recognizing the endogenous and ectopically-expressed ERK8 proteins. (Cai N L, et al., 2017)
Service Options
Creative BioMart has a highly experienced team of professionals capable of providing comprehensive analytical services for different types of antibodies suitable for a wide range of applications. We have successfully completed numerous challenging antibody analysis projects, helping our customers save time and effort. We offer flexible antibody analysis strategies and advanced technology options to meet the specific needs of each project. Our service options include, but are not limited to the following:
| Molecular Characterization | ||
| Molecular weight determination | Antibody sequence analysis | Antibody homogeneity analysis |
| Antibody purity analysis | Antibody stability analysis | Antibody quantification and titration |
| Antibody structure analysis | Antibody aggregation analysis | Antibody charge heterogeneity analysis |
| Amino acid analysis | Peptide mapping | Analysis of post-translational modifications |
| Functional Assessment | ||
| Affinity measurement | Ligand-binding assays | Measurement of antigen-antibody interactions |
| Structure-function analysis | Cell-based potency analysis | Evaluation of antibody effector functions |
* If you can't find what you are looking for in the options above, please fill out the online inquiry form and let us know more details.
Creative BioMart has an experienced scientific team to provide professional antibody analysis services to match the specific needs of our customers. Our services can comprise an individual or a comprehensive analysis. We also provide a full set of services from antigen preparation to antibody production to help our customers obtain the required antibodies as soon as possible. If you are interested in our services, please do not hesitate to contact us.
References
- Cai N L, et al. Purification and characterization of a highly specific polyclonal antibody against human extracellular signal-regulated kinase 8 and its detection in lung cancer. PLoS One, 2017, 12(9): e0184755.
- Beck A, et al. Characterization of therapeutic antibodies and related products. Analytical chemistry, 2013, 85(2): 715-736.