Biomolecular Interaction Services for Phosphorylation Research
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INQUIRYCreative BioMart provides customized biomolecular interaction analysis services to accelerate kinase/phosphatase biology research and pharmaceutical development. With strong expertise in peptide and protein science and years of experience in providing flexible solutions to customers worldwide, Creative BioMart guarantees a work plan tailored to your specific needs and ensures the quality, reliability, and reproducibility of the deliverables.
Background
Biomolecular interaction analysis as a focus of both basic sciences and applied research has become the center of attention in a wide range of disciplines, from biology to medicine. Proteins and peptides are fundamental components of cells. They perform important biological functions and are involved in almost all physiological processes in the body that are essential for life. The biological properties of peptides and proteins depend largely on their physical interaction with other molecules. Exploring the interactions between peptides and proteins and their interactions with other molecules has been a frontier and hotspot in the field of life science research.
Kinases and phosphatases are essential for signal transduction and control of most cellular processes. The interactions of kinases and phosphatases with their regulatory subunits and substrates are the basis of cellular regulation. The comprehensive analysis of their interaction networks is important for understanding biological systems and functions and for applying the gained knowledge to the design of new drugs.
Figure 1. Systematic Mapping of Kinase Interactions by AP-MS. (Buljan M, et al., 2020)
What We Offer
Creative BioMart offers comprehensive biomolecular interaction services to characterize and analyze virtually all types of biomolecular interactions, covering a diverse range of biomolecules from nucleic acids and proteins to drugs. Our advanced technology platform enables high-throughput characterization of biomolecule interactions.
| Types of Biomolecular Interactions | Featured Techniques | |
| DNA-RNA interactions | Peptide-carbohydrate interactions | Surface plasmon resonance (SPR) |
| DNA-DNA interactions | Peptide-metal ion interactions | Fluorescence resonance energy transfer (FRET) |
| RNA-RNA interactions | Peptide-protein interactions | Isothermal titration calorimetry (ITC) |
| Nucleic acid-lipid membrane interactions | Protein-protein interactions | Bio-layer interferometry (BLI) |
| Nucleic acid-carbohydrate interactions | Protein-nucleic acid interactions | UV-visible absorption spectroscopy |
| Nucleic-metal ion interactions | Protein-lipid interactions | Raman spectroscopy |
| Nucleic acid-graphene interactions | Protein-carbohydrate interactions | Surface-enhanced laser desorption/ionization (SELDI) |
| Nucleic acid-drug interactions | Protein-graphene oxide interactions | Fourier transform infrared spectroscopy (FTIR) |
| Nucleic acid-peptide interactions | Drug-drug interactions | Microscale thermophoresis (MST) |
| Peptide-peptide interactions | Drug-polymer interactions | Microneedle biosensor |
| Peptide-lipid interactions | Natural product-drug interactions | Molecular docking |
If you can't find what you are looking for in the options above, please fill out the online inquiry form and let us know more details.
Why Choose Us
- One-stop services from experimental design, sample preparation, to data analysis.
- Customized work plans and optimized strategies for each project to achieve specific purposes.
- Scalable platform and a wide range of optional services.
- High throughput capacity, high-quality, fast delivery, and low cost.
- Strict confidentiality of project information provided by our customers.
Custom Project Workflow
Creative BioMart' strong team of biologists, chemists, and pharmacologists is dedicated to helping you save time and effort, making every effort to facilitate your way to project success. If you require any further information, please feel free to contact us. We look forward to working with you.
References
- Buljan M, et al. Kinase Interaction Network Expands Functional and Disease Roles of Human Kinases. Molecular cell, 2020, 79(3): 504-520. e9.
- Breitkreutz A, et al. A global protein kinase and phosphatase interaction network in yeast. Science, 2010, 328(5981): 1043-1046.