In Vitro Phosphatase Screening & Profiling
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INQUIRYCreative BioMart has a scientific team specializing in phosphatase biology and drug discovery, providing comprehensive in vitro phosphatase screening and profiling services for biological research and drug development. We offer state-of-the-art techniques and equipment to help our customers overcome challenges and bottlenecks.
Background
Reversible protein phosphorylation is a common mechanism used by cells to propagate or terminate cell signaling. Kinases and phosphatases alter protein conformation and/or protein interactions by the addition or removal of phosphates. Phosphorylation/dephosphorylation reactions have an impact on substrate activity, half-life, function, and their subcellular localization. The antagonistic activities of these enzymes are involved in the regulation of multiple cellular processes. Therefore, the underlying molecular mechanisms controlling phosphorylation/dephosphorylation are of great physiological importance. In fact, phosphatases have been largely neglected while most kinases have been well characterized.
Imbalance between phosphorylation and dephosphorylation have been demonstrated to be implicated in the development and progression of a myriad of diseases, making kinases and phosphatases promising therapeutic targets. Due to many difficulties in studying phosphatases in the past and unsuccessful attempts to develop drugs targeting them, they have long been considered undruggable. However, tremendous progress has been made in phosphatase research over the past 20 years. New and creative methods for phosphatase screening and profiling have been developed to address specific challenges, paving the way for the development of drugs targeting phosphatases. Phosphatase have regained a strong attention.
Figure 1. Consequences of the targeted disruption of select phosphatase complexes. (McConnell J L & Wadzinski B E., 2009)
Technical Capabilities
With extensive knowledge and unparalleled experience in phosphatase biology, we have established an integrated phosphatase screening & profiling platform with the largest portfolio of phosphatase assays, enabling our scientific team to offer customized services to meet your individual needs.
Our Services
Creative BioMart offers comprehensive services for in vitro phosphatase screening and profiling to support our customers’ cutting-edge research and accelerate their journey to success. If you have any additional requirements, please fill out the online inquiry form and let us know more details.
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Enzymatic Characterization
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Small Molecule Screening
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Phosphatase Activity Assays
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Substrate Profiling
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Creative BioMart has extensive knowledge and years of experience in kinase/phosphatase biology and pharmaceutical development. Equipped with state-of-the-art facilities and technology, we are able to deliver trustworthy and comprehensive phosphatase screening & profiling services to meet our customers’ requirements. We guarantee that any data or details you provide will be kept strictly confidential. If you are interested in our services, please do not hesitate to contact us.
References
- McConnell J L & Wadzinski B E. Targeting protein serine/threonine phosphatases for drug development. Molecular pharmacology, 2009, 75(6): 1249-1261.
- Lazo J S, et al. New approaches to difficult drug targets: the phosphatase story. SLAS DISCOVERY: Advancing Life Sciences R&D, 2017, 22(9): 1071-1083.