Structural Characterization of Kinase/Phosphatase Family
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INQUIRYCreative BioMart has a scientific team specializing in structural biology and bioinformatics to provide comprehensive structure characterization services for kinase/phosphatase biology research and drug development. We offer state-of-the-art techniques and equipment to help our customers overcome challenges and bottlenecks in structural characterization.
Background
In both prokaryotes and eukaryotes, protein post-translational modifications by reversible phosphorylation with kinases and phosphatases regulate key signaling pathways in cells. The addition or removal of a phosphate group may result in altered protein activity, subcellular localization, or interactions. The relationships between substrates and kinases/phosphatases are vital in cellular homeostasis. The flow of information in cells can be directed via reversible protein phosphorylation. Kinase/phosphatase signaling pathways appear to be staggeringly complex, as many molecular details are still poorly understood.
Understanding the complexity of phosphorylation is of great significance. Aberrant phosphorylation has been demonstrated to cause or contribute to a wide variety of human diseases, making kinases and phosphatases promising therapeutic targets. Structural characterization of kinase/phosphatase family has made a significant contribution to our understanding of molecular mechanisms regulating their activity. The crystal structures of several kinases and phosphatases have been determined, providing more insights into underlying molecular mechanisms of cell signaling & regulation, and promoting innovation in drug development.
Figure 1. Representatives of the CDKL kinase family. (Endicott J A & Noble M E M, 2013)
Technical Capabilities
Creative BioMart has a team of experienced scientists capable of providing different primary and higher-order structural characterization strategies for various types of samples based on our advanced technology platform.
Our Services
Creative BioMart offers comprehensive services for structure analysis to support our customers' cutting-edge research and accelerate their journey to success. If you have any additional requirements, please fill out the online inquiry form and let us know more details.
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Crystallization and Structure Determination
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Structure Prediction and Analysis
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Structure Validation
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Creative BioMart has extensive knowledge and years of experience in kinase/phosphatase biology, structural biology, bioinformatics and pharmaceutical development. Equipped with state-of-the-art facilities and technology, we are able to deliver trustworthy and comprehensive structural characterization services to meet our customers' requirements. We guarantee that any data or details you provide will be kept strictly confidential. If you are interested in our services, please do not hesitate to contact us.
References
- Endicott J A & Noble M E M. Structural characterization of the cyclin-dependent protein kinase family. Biochemical Society transactions, 2013, 41(4): 1008-1016.
- Delumeau O, et al. Functional and structural characterization of RsbU, a stress signaling protein phosphatase 2C. Journal of Biological Chemistry, 2004, 279(39): 40927-40937.