Analysis of Tissue-Specific Phosphorylation
HomeAnalysis of Tissue-Specific Phosphorylation
INQUIRYCreative BioMart provides expertise and experience in the comprehensive analysis of tissue-specific phosphorylation to support kinase/phosphatase biology research and drug development. We offer state-of-the-art techniques and equipment to help our customers overcome the challenges and bottlenecks of elucidating phosphorylation events.
Background
Protein phosphorylation is a widely studied post-translational modification (PTM) involved in almost all cellular processes, spanning from cell cycle to metabolism. It has been reported that phosphorylation sites display tissue-specific preferences. The phosphorylation of cellular proteins is tightly controlled by kinases and phosphatases with different expression levels in different tissues, thus phosphorylation and dephosphorylation are dynamic events with restricted spatial and temporal distribution. The activity of kinases and phosphatases are themselves fine-tuned by phosphorylation events, generating a complex regulatory pattern.
Indeed, deregulated signaling pathways is usually a hallmark of many diseases. Phosphorylation pathways have also been shown to be implicated in the pathogenesis of several severe diseases, such as cancer and diabetes. Kinase/phosphatase genes with elevated expression levels in particular tissues can serve as a starting point to understand their biological functions and the underlying mechanisms of related diseases. This highlights the importance of developing techniques that allow for comprehensive and quantitative determinations of tissue-specific phosphorylation.
Figure 1. Overview of Tissue-Specific Phosphorylation. (Huttlin E L, et al., 2010)
Technical Capabilities
With extensive knowledge and unparalleled experience in kinase/phosphatase biology, we have established an integrated technology platform with the largest portfolio of assay formats, enabling our scientific team to offer customized services to meet your individual needs.
Our Services
Creative BioMart offers comprehensive services for tissue-specific phosphorylation analysis to support our customers’ cutting-edge research and accelerate their journey to success. If you have any additional requirements, please fill out the online inquiry form and let us know more details.
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Identification of Phosphoproteins in Tissues
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Tissue-Specific Expression of Kinases/Phosphatases
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Analysis of Tissue-Specific Phosphorylation Sites
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Creative BioMart has extensive knowledge and years of experience in kinase/phosphatase biology and pharmaceutical development. Equipped with state-of-the-art facilities and technology, we are able to deliver trustworthy and comprehensive analysis of tissue-specific phosphorylation to meet our customers’ requirements. We guarantee that any data or details you provide will be kept strictly confidential. If you are interested in our services, please do not hesitate to contact us.
References
- Huttlin E L, et al. A tissue-specific atlas of mouse protein phosphorylation and expression. Cell, 2010, 143(7): 1174-1189.
- Lundby A, et al. Quantitative maps of protein phosphorylation sites across 14 different rat organs and tissues. Nature communications, 2012, 3(1): 1-10.