In Vitro Kinase Screening & Profiling
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INQUIRYCreative BioMart has a scientific team specializing in kinase biology and drug discovery, providing comprehensive in vitro kinase screening and profiling services for biological research and drug development. We offer state-of-the-art techniques and equipment to help our customers overcome challenges and bottlenecks.
Background
Kinases catalyze the transfer of phosphoryl groups from ATP to their substrates to regulate the structures and functions of proteins in prokaryotic and eukaryotic cells. The functions of kinases are often mediated by their target substrates. Identifying kinase-substrate interactions is important for the elucidation of the physiological functions of these important enzymes. Under normal conditions, many cellular processes such as cell signal transduction, cell differentiation and growth, and cell death can be finely orchestrated by specific kinases. Under pathological conditions, disruption of intracellular signaling networks due to dysregulation of kinase activities may cause a variety of diseases. Over the past years, kinases have become one of the most important class of drug target in the pharmaceutical industry. Kinase screening and profiling techniques covering multiple assay formats are powerful tools for identifying kinase-interacting substrates, potential drug targets and novel drug candidates.
Figure 1. A novel approach to kinase-inhibitor discovery. (Goldstein D M, et al., 2008)
Technical Capabilities
With extensive knowledge and unparalleled experience in kinase biology, we have established an integrated kinase screening & profiling platform with the largest portfolio of kinase assays, enabling our scientific team to offer customized services to meet your individual needs.
Our Services
Creative BioMart offers comprehensive services for in vitro kinase screening and profiling to support our customers’ cutting-edge research and accelerate their journey to success. If you have any additional requirements, please fill out the online inquiry form and let us know more details.
Creative BioMart has extensive knowledge and years of experience in kinase/phosphatase biology and pharmaceutical development. Equipped with state-of-the-art facilities and technology, we are able to deliver trustworthy and comprehensive kinase screening & profiling services to meet our customers' requirements. We guarantee that any data or details you provide will be kept strictly confidential. If you are interested in our services, please do not hesitate to contact us.
References
- Goldstein D M, et al. High-throughput kinase profiling as a platform for drug discovery. Nature reviews Drug discovery, 2008, 7(5): 391-397.
- Wang Y & Ma H. Protein kinase profiling assays: a technology review. Drug Discovery Today: Technologies, 2015, 18: 1-8.