Kinase Screening

Kinase Screening

INQUIRY

Creative BioMart provides high-quality kinase substrate screening and small molecule screening services to fully support kinase biology research and drug development. With extensive knowledge and unparalleled experience in kinase screening & profiling, we offer a large collection of biochemical and cell-based kinase assays to help our customers resolve issues and overcome challenges.

Background

Kinases transfer the γ-phosphate of ATP to hydroxyl groups in specific substrates. The human kinome encoding 634 kinases (pseudokinases included) comprise one of the largest families of homologous proteins. Kinases play an integral role in cell signal transduction. Overexpression and/or dysregulation of kinases result in many diseases such as cancer, neural disorders, inflammatory diseases, and metabolism problems, making them one of the most promising groups of drug targets. Currently, approximately one quarter of all research expenditures on drug development are focused on kinases.

Given the clinical importance of kinase-targeting drugs, many technologies and platforms have been developed for identifying kinase substrates and discovering small molecules against kinases. Over the past few years, numerous biotech and pharmaceutical companies have established high-throughput platforms for kinase screening. The industry offering kinase assays, assay kits, and kinase analysis services has begun to thrive, however, at the same time the plethora of different assay formats also poses a great challenge in selecting easy-to-use and cost-effective technology with low false-positive and false-negative rates.

Service Options

Creative BioMart has established a state-of-the-art screening platform to help our customers identify kinase substrates and potential new small molecules targeting kinases. Our scientific team will work closely with our customers to help them accomplish the objective of their research and accelerate drug discovery programs.

Kinase Substrate Screening

Comprehensive kinase substrate screening is necessary to understand kinase signaling networks and kinase-substrate interactions involved in disease pathology, thus contributing to the development of more specific kinase-targeted drugs. Creative BioMart provides our customers with a comprehensive selection of kinase substrate screening services to help them map kinase-substrate relationships and elucidate signaling pathways.

Small Molecule Screening against Kinases

To identify novel targets and elucidate their underlying biological mechanisms, screening for selective small molecules that act against kinases is desired. The development of small molecule kinase drugs is developing rapidly and has emerged as one of the most important research areas. Creative BioMart has set up a state-of-the-art high-throughput screening platform to help our customers identify potential new small molecules targeting kinases and thus accelerate the overall drug development process.

Features of Our Services

• Massive kinome coverage.
• Customized services based on a large collection of kinase assays.
• Fast turnaround time and competitive price.

Creative BioMart is an advanced biotech company within the field of kinase/phosphatase biology. We offer our expertise in establishing assays for kinase screening & profiling. The extensive experience of our scientific team translates into the robust wealth of knowledge that we use to provide you with the highest quality of service. We also supply a wide range of ready-to-use products for kinase screening. If you are interested in our services or products, please do not hesitate to contact us.

References

• Comley J. KINASE SCREENING and PROFILING. Drug Discovery, 2006, 7: 27.
• Ma H, et al. The challenge of selecting protein kinase assays for lead discovery optimization. Expert opinion on drug discovery, 2008, 3(6): 607-621.