RIP (RIPK1) (NM_003804) Human Recombinant Protein
Product Information
| Product Name | RIP (RIPK1) (NM_003804) Human Recombinant Protein |
| Cat.No | RP75266 |
| Description | Purified recombinant protein of Human receptor (TNFRSF)-interacting serine-threonine kinase 1 (RIPK1), full length, with N-terminal HIS tag, expressed in E.Coli, 50ug |
| Species | Human |
| Expression Host | E. coli |
| Expression cDNA Clone or AA Sequence | Protein Sequence (showhide) A DNA sequence encoding human full-length RIPK1 |
| Tag | N-His |
| Predicted MW | 75.8 kDa |
| Concentration | >50 ug/mL as determined by microplate BCA method |
| Purity | > 80% as determined by SDS-PAGE and Coomassie blue staining |
| Buffer | 25mM Tris, pH8.0, 150 mM NaCl, 10% glycerol, 1 % Sarkosyl |
| Storage | Store at -80°C. |
| Stability | Stable for 12 months from the date of receipt of the product under proper storage and handling conditions. Avoid repeated freeze-thaw cycles. |
| RefSeq | NP_003795 |
| Locus ID | 8737 |
| UniProt ID | Q13546, A0A024QZU0 |
| Cytogenetics | 6p25.2 |
| RefSeq Size | 3864 |
| Refseq ORF | 2013 |
| Synonyms | AIEFL; IMD57; RIP; RIP-1; RIP1 |
| Summary | This gene encodes a member of the receptor-interacting protein (RIP) family of serine/threonine protein kinases. The encoded protein plays a role in inflammation and cell death in response to tissue damage, pathogen recognition, and as part of developmental regulation. RIPK1/RIPK3 kinase-mediated necrosis is referred to as necroptosis. Genetic disruption of this gene in mice results in death shortly after birth. [provided by RefSeq, Aug 2017] |
| Protein Families | Druggable Genome, Protein Kinase |
| Protein Pathways | Apoptosis, Cytosolic DNA-sensing pathway, RIG-I-like receptor signaling pathway, Toll-like receptor signaling pathway |