Analysis of Kinase Signaling Networks

Analysis of Kinase Signaling Networks

INQUIRY

Creative BioMart provides overall solutions for the analysis of kinase signaling networks to help elucidate the role of phosphorylation in various cellular processes. We provide access to a wide range of products and services covering virtually all kinase targets of interest to our customers. Our scientific team will work closely with our customers to customize solutions for their projects, helping them save time and effort.

Introduction to Kinase Signaling Networks

The rapid development of high-throughput proteomics has revealed an increasing number of phosphorylation events in eukaryotic cells, implying large and complicated phosphorylation signaling networks in various cellular processes. Kinases are enzymes responsible for catalyzing the transfer of phosphate groups from phosphate-donating molecules (e.g., ATP) to specific substrates. Due to their key regulatory role in most cellular processes, kinases are important components of the protein-protein interactome and signal transduction. Although a large number of phosphorylation sites have been identified and accumulated evidence has suggested a close association between kinases and diseases, only a small fraction of kinases and their interactions have been well recognized, and the linkage between each phosphorylation site and the responsible kinase remains largely unknown. Therefore, analysis of kinase signaling networks is critical for deciphering cell signaling mechanisms. The presented interaction maps are a valuable resource for assisting biomedical studies to elucidate pathogenic mechanisms of disease onset and progression.

Overall Solutions

• Kinase-Substrate Interactions

  Creative BioMart provides complete and efficient solutions for the identification of interactions between kinases and substrates to help elucidate the roles of distinct kinases in different cellular processes and to facilitate the development of specific inhibitors.

• Functional Landscape of Kinase Signaling Networks

  Creative BioMart specializes in developing assays such as proteomics assays, bioinformatic analysis, and kinase functional assays to aid in deciphering kinase signaling networks and obtaining new insights into the regulatory mechanisms and functions of kinase signaling pathways.

• Kinase Signaling Networks in Diseases

  Creative BioMart has a scientific team with extensive experience in kinase drug development working to identify disease-related kinase signaling networks and explore the pathogenesis of these diseases, providing important clues to identify novel kinases as druggable targets.

• Diverse Kinase Pathways

  Creative BioMart has an in-depth understanding of diverse kinase signaling pathways, including MAPK/ERK pathways, JNK pathways, AMPK pathways, PI3K/AKT/mTOR pathways, etc. We also work on the refinement and expansion of kinase signaling pathways of interest to our customers.

Featured Services

• A

  Protein Analysis Services

• B

  Biomolecular Interaction Services

• C

  Ligand Binding Assays

• D

  Kinase Functional Assays

• E

  Kinase Substrate Screening

• F

  In Vivo Functional Characterization

Creative BioMart is a trusted solution provider with many years of experience in kinase/phosphatase biology research and drug development. We have always been committed to providing our customers with high-quality products and customized services to accelerate their cutting-edge research and drug development pipeline. We fully support your project every step of the way to success.

References

• Buljan M, et al. Kinase interaction network expands functional and disease roles of human kinases. Molecular cell, 2020, 79(3): 504-520. e9.
• Amano M, et al. Comprehensive analysis of kinase-oriented phospho-signalling pathways. The Journal of Biochemistry, 2019, 165(4): 301-307.