Analysis of Phosphatase Interaction Networks

Analysis of Phosphatase Interaction Networks

INQUIRY

Creative BioMart provides overall solutions for the analysis of phosphatase interaction networks to help elucidate the role of phosphorylation in various cellular processes. We provide access to a wide range of products and services covering virtually all phosphatase targets of interest to our customers. Our scientific team will work closely with our customers to customize solutions for their projects, helping them save time and effort.

Introduction to Phosphatase Interaction Networks

A growing number of findings have confirmed that protein phosphatases are essential components of signal transduction and promising therapeutic targets for diverse diseases. They play important regulatory functions in a wide range of cellular processes through their interactions with substrates, regulatory subunits, and kinases. Therefore, understanding these interactions is critical to unravel the function of phosphatases. However, the functions of phosphatase and their interactions are much less understood than those of kinases, largely due to the promiscuous phosphatase activity and their low intrinsic substrate specificity. Thus, a complete characterization of phosphatase complexes and a comprehensive analysis of phosphatase interaction networks are a prerequisite for understanding their mechanism of action and physiological roles. For now, much work remains to be done in defining the phosphatase interaction network and understanding global patterns of phosphatase activity.

Overall Solutions

• Phosphatase-Substrate Networks

  Creative BioMart provides customized solutions for identifying interactions between phosphatases and their substrates according to the customer requirements. We provide an initial glimpse into the phosphatase interaction landscape and support the dissection of their functions in cellular regulation.

• Kinase-Phosphatase Interactions

  Differential interactions of kinases with phosphatases exhibit unique signal processing characteristics to meet specific cellular requirements. Creative BioMart offers bioinformatics tools and databases to predict kinase-phosphatase interactions that underpin cellular information flow and reveal the mechanisms of phosphorylation.

• Systematic Analysis of Phosphatase Interactome

  Creative BioMart has established a platform covering a range of advanced techniques such as TAP-MS, AP-MS, and proteomics to help delineate the interaction landscape of phosphatases and expand knowledge of the biological roles of poorly studied phosphatases.

• Phosphatase Interaction Networks in Diseases

  Creative BioMart has a project team with years of experience in phosphorylation research and drug development dedicated to helping our customers better understand the link between phosphatases and diseases, providing new insights into the disease mechanisms and druggable phosphatase targets.

Featured Services

• A

  Custom Protein Production

• B

  Protein Analysis Services

• C

  Biomolecular Interaction Services

• D

  Substrate Profiling of Phosphatases

• E

  Phosphatase Activity Assays

• F

  In Vivo Identification of Phosphatase Substrates

Creative BioMart is a trusted solution provider with many years of experience in kinase/phosphatase biology research and drug development. We have always been committed to providing our customers with high-quality products and customized services to accelerate their cutting-edge research and drug development pipeline. We fully support your project every step of the way to success.

References

• Yadav L, et al. Systematic analysis of human protein phosphatase interactions and dynamics. Cell systems, 2017, 4(4): 430-444. e5.
• Breitkreutz A, et al. A global protein kinase and phosphatase interaction network in yeast. Science, 2010, 328(5981): 1043-1046.